여름정기학술대회
2022여름초록
발표자 및 발표 내용
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포스터발표 |
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Brief Oral Presentation 발표신청 |
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국가 |
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공동저자
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접수자
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Di(isononyl) cyclohexane-1,2-dicarboxylate (DINCH) is a high
molecular weight plasticizer. It was developed for use in polyvinyl chloride
plastics (PVC), largely as an alternative to di-(2-ethylhexyl) phthalate (DEHP)
and di-isononyl phthalate (DiNP) (Crespo et al., 2007; EFSA, 2006). Because it
is not chemically bound to the plastics, DINCH can be released into the
environment during use, and can also migrate into foods or indoor environment
where human exposure to DINCH can occurr.
The known metabolites of DINCH are
cyclohexane-1,2-dicarboxylic monoisononyl ester (MINCH), cyclohexane-1,2-dicarboxylic
mono hydroxyisononyl ester (OH-MINCH), cyclohexane-1,2-dicarboxylic mono
oxoisononyl ester (oxo-MINCH), and cyclohexane-1,2-dicarboxylic mono
carboxyisononyl ester (cx-MINCH) and cyclohexane-1,2-dicarboxylic acid (CHDA)
(Koch et al., 2013). We want to identify which biomarker can accurately reflect
the exposure to DINCH. We prepared 30 Korean urine by solid-phase extraction
and analyzed 4 metabolites of DINCH using UHPLC-MS/MS.
Urinary median concentration (detection rate) of the 4
metabolites were as follows; CHDA 3.3 (100%), cx-MINCH ND (43%), OH-MINCH ND
(33%), MINCH ND (10%). In recent study, DINCH was found the major pollutant in
indoor dust. But most of the metabolites were not detected in human urine,
except CHDA. This results suggest that CHDA might the most appropriate
biomarker of exposure to DINCH.
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