2026년
한국질량분석학회 여름학술대회 및 총회
2026. 08.19 (수) ~ 2026. 08.21 (금)
창원컨벤션센터(CECO)
초록검색
| | 한국질량분석학회 여름학술대회 및 총회 Brief Oral Presentaionof Selected Posters | |
| 제목 | Synthesis of TiO₂ nanostructures for Small Molecule Detection and Imaging Using SALDI-TOF MS |
|---|---|
| 작성자 | 김재웅 (한림대학교) |
| 발표구분 | 포스터발표 |
| 발표분야 | 2. Mass Spectrometry in Elemental Analysis |
| 발표자 |
김재웅 (한림대학교) |
| 주저자 | 김재웅 (한림대학교) |
| 교신저자 |
박종민 (한림대학교) |
| 저자 |
김재웅 (한림대학교) 박종민 (한림대학교) 김강현 (한림대학교) 정은서 (한림대학교) |
|
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is widely used for rapid and high-throughput analysis of biomolecules, including proteins and lipids. However, organic matrices often produce intense background signals in the low-molecular-weight region through fragmentation during laser irradiation, limiting small-molecule detection and interpretation. To overcome this limitation, surface-assisted laser desorption/ionization time-of-flight mass spectrometry (SALDI-TOF MS) has been investigated as an alternative. Among SALDI matrices, TiO₂ has attracted attention because its optical absorption and photocatalytic properties can promote efficient analyte desorption and ionization. In this study, synthesized TiO₂ nanostructures generated lower background signals in the low-molecular-weight region than organic matrices. They also exhibited soft ionization characteristics comparable to P25 and stable signal reproducibility in repeated measurements. Furthermore, the spatial distributions of endogenous and exogenous candidate ions in fingerprint samples were visualized using SALDI-TOF MSI. These findings demonstrate the potential of synthesized TiO₂ nanostructures as inorganic matrices for reproducible low-molecular-weight SALDI-TOF MS and MSI. |
|