2024. 08.28 (수) ~ 2024. 08.30 (금)
군산새만금컨벤션센터(GSCO)
제목 | Measurement of lipid changes in Parkison’s-induced mouse model using mass spectrometery |
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작성자 | 손현경 (한국표준과학연구원(KRISS)) |
발표구분 | 포스터발표 |
발표분야 | 4. Medical / Pharmaceutical Science |
발표자 |
Hyun Kyong Shon (KRISS) |
주저자 | Tae Geol Lee (KRISS) |
교신저자 |
Tae Geol Lee (KRISS) Jin Gyeong Son (KRISS) |
저자 |
Tae Geol Lee (KRISS) Hyun Kyong Shon (KRISS) Sun Young Lee (KRISS) Jeong Hee Moon (KRIBB) Ga Seul Lee (KRIBB) Jin Gyeong Son (KRISS) |
Parkinson’s disease is a chronic, progressive neurological disorder that affect motor control, and its exact cause is not yet fully understood. As far as we know, dopamine-producing cells in a specific area of the brain called the substantial nigra (SN), which is part of the nucleus accumbens, progressively degenerate, resulting in symptoms such as tremors, rigidity, bradykinesia, and postural instability. In addition to these motor symptoms, cognitive impairment and neuropsychiatric symptoms also occur which is leading to dementia and may significantly reduce the quality of life. Dopamine is a crucial neurotransmitter that act on the basal ganglia to enable the body to move with precision, but it is not yet understood why dopamine neurons are declined in Parkinson disease, which is most common degenerative brain disease after Alzheimer’s disease. There is no known way to cure Parkinson’s disease, and only early diagnosis can alleviate its symptoms.
Mass spectrometry imaging is a powerful analytical tool that can be used to study the molecular changes that occur in Parkinson’s disease brain. In this work, we made a 6-OHDA (hydroxydopamine) mouse model which is Parkinson’s disease by injection into the substantia nigra (SN) region at a concentration of 20 mg/kg to cause apoptosis of dopaminergic neurons. When an abnormality occurs in the SN, the pathway responsible for the transport of about 80 % of dopamine is disrupted, resulting in the Parkinson’s disease IHC staining result shows that more than 90 % of neuronal cell death was confirmed in all n= 3 mice in the SN and Striatum (ST) regions, and metabolite changes in the SN and ST regions were confirmed using coronal section tissue of the mouse brain. As a results of mass imaging, it was confirmed that the signal increased or decreased in SN region. Interestingly, we found a significant increase in the signal of three molecules in the SN region. We will attempt MS/MS for molecular identification. |