2024. 08.28 (수) ~ 2024. 08.30 (금)
군산새만금컨벤션센터(GSCO)
제목 | 2-Dimensional Mass Spectrometry Imaging using KBSI ToF-SIMS |
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작성자 | 백지영 (한국기초과학지원연구원) |
발표구분 | 포스터발표 |
발표분야 | 1. Fundamental & Instrumentation |
발표자 |
백지영 (한국기초과학지원연구원) |
주저자 | 백지영 (한국기초과학지원연구원) |
교신저자 |
최창민 (한국기초과학지원연구원) |
저자 |
백지영 (한국기초과학지원연구원) 임희진 (한국기초과학지원연구원) 서정주 (한국기초과학지원연구원) 최창민 (한국기초과학지원연구원) |
Mass spectrometry imaging (MSI) technique provides spatial distribution information of molecular species in a variety of samples. MSI was introduced by Castaing and Slodzian using secondary ionization mass spectrometry (SIMS) to study semiconductor surfaces. Matrix-assisted laser desorption ionization (MALDI) and desorption electrospray ionization (DESI) can be used as MSI technique. MALDI and DESI MSI are mainly applied to relatively large molecules such as peptide, proteins and lipids. Recently, we have developed a time-of-flight secondary ion mass spectrometry (ToF-SIMS) and Ar-gas cluster ion beam (GCIB) to analyze an organic surface sample. Here, we performed MSI for two-dimensional (2D) samples made from the organic dye rhodamine 6G and prezatide copper acetate (GHK-Cu), an example of a biological sample, using a home-built Ar-GCIB and ToF-SIMS. Two-dimensional organic patterned samples were prepared by a photoresist (PR) patterning silicon wafer coated with parylene, spin-coating rhodamine 6G or GHK-Cu solution, and removing parylene film from an organic sample spincoated silicon wafer piece. The size of pattern on silicon wafer is minimum 80 μm and maximum 500 μm. Finally, 2D images of patterned samples were obtained by rastering 20 kV Ar-GCIB. From the obtained images, we confirmed our Ar-GCIB could be obtain 2D images of patterns less than 100 μm and the reliability of the equipment we developed. |