이진행 (한국기초과학지원연구원)

황금숙 (한국기초과학지원연구원)

이진행 (한국기초과학지원연구원)

정영애 (한국기초과학지원연구원)

김원 (서울특별시 보라매병원)

이승미 (서울대학교병원)

황금숙 (한국기초과학지원연구원)

Gestational diabetes mellitus (GDM) is a metabolic disorder characterized by impaired glucose tolerance that develops during pregnancy. Despite its prevalence and potential health risks, predictive or diagnostic marker of GDM have not been revealed clearly. In this study, we performed targeted bile acid analysis from serum samples of non-GDM pregnant women (n = 118) and GDM pregnant women (n=118) using ultra-performance liquid chromatography-triple quadrupole mass spectrometry (UPLC-TQ MS). Serum samples were collected at 10-14 weeks before GDM diagnosis and 24-28 weeks. As a result, total primary bile acids were significantly increased in GDM patients at 10-14 weeks. Total secondary bile acids had no significant changes between non-GDM and GDM patients at both time points. Especially, glyco-/tauro- conjugated primary bile acids (glycocholic acid, taurocholic acid, glycochenodeoxycholic acid, taurochenodeoxycolic acid) were significantly increased in GDM patients at 10-14 weeks. All of the bile acids exhibited no significance between non-GDM and GDM patients at 24-28 weeks except for taurodeoxycholic acid. This study suggests that serum bile acids change largely only at early pregnancy and several primary bile acids can be predictive markers for early GDM diagnosis.

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