Suyeon Park (중앙대학교)

Dong-Kyu Lee (중앙대학교)

Suyeon Park (중앙대학교)

Minki Shim (중앙대학교)

Dong-Kyu Lee (중앙대학교)

Novel brominated flame retardants (NBFRs), used to provide fire resistance in various products, are expected to face regulatory restrictions, and grains, which are widely consumed globally and may pose health risks as a potential exposure route, should be closely monitored. In this study, 10 NBFRs in white rice were quantified using a modified dispersive solid-phase extraction (dSPE) method combined with gas chromatography electron ionization tandem mass spectrometry. Ultrasonic-assisted extraction (UAE) with optimized dichloromethane/hexane mixture solvent efficiently extracted NBFRs, and florisil and silica used as sorbents in dSPE　minimized matix effects. Since NBFRs have low volatility under standard GC conditions, a DB-5HT column was applied. The method was validated following CODEX guidelines. Excellent linearity was achieved with R² values ≥ 0.99, along with clear selectivity. A high-temperature GC column with a thin film significantly enhanced sensitivity, enabling LOQs from 0.05 to 5.00 ng/g. Recoveries across various concentration levels ranged from 64% to 119%. Precision, expressed as RSD, fell between 0.19% and 22.3%, all within CODEX-acceptable limits. These findings confirm the modified dSPE method as a reliable platform for analyzing NBFRs in white rice. Its cost and time efficiency suggest strong potential for wider environmental applications. This research was supported by a grant (22194MFDS004) from Ministry of Food and Drug Safety in 2025.

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