Hyo Min Lee (Kyungpook National University)

Young Ran Yoon (Kyungpook National University)

Hyo Min Lee (Kyungpook National University)

Young Ran Yoon (Kyungpook National University)

Cholecalciferol regulates calcium homeostasis and phosphorus absorption and plays a crucial role in bone health. Its deficiency can increase the risk of fracture and impact related metabolism. However, nearly half of Koreans (47.5%) has insufficient levels of vitamin D. Furthermore, age-related variations in basal metabolism may also influence the metabolic profile when cholecalciferol is administered. Therefore, this study aimed to compare the metabolic changes following cholecalciferol administration in young and elderly individuals. A single oral dose of 20 mg cholecalciferol was administered to both young (n=5; 24.0 [23–29] years) and elderly (n=10; 69.5 [64–77] years) subjects, and their plasma samples were collected before and 12 hours after administration. Targeted metabolomics analysis was performed using the Biocrates AbsoluteIDQ^® p180 kit. The younger group of subjects who received cholecalciferol showed a significant increase in 13 metabolites associated with the metabolism of arginine, phenylalanine, and tyrosine. However, 11 metabolites-primarily related to the metabolism of arginine and glutathione-decreased in the elderly group after receiving cholecalciferol. These results suggest that cholecalciferol influences amino acid metabolism including pathways related to nitrogen excretion and energy storage. Further studies are needed to explore correlations between the metabolomic changes observed in young and elderly groups following cholecalciferol administration.

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