이지원 (중앙대학교)

한상범 (중앙대학교)

이지원 (중앙대학교)

한상범 (중앙대학교)

 Since the Stockholm Convention, global efforts have aimed to reduce persistent organic pollutants (POPs). In this study, we developed a simultaneous analytical method using GC-MS for four siloxanes (D4, D5, D6, D7) and four synthetic musks (HHCB, AHTN, MX, MK), which are considered as candidate POPs, in mackerel, pork loin, fish cake, and squid. To minimize the loss of  highly volatile and nonpolar siloxanes, a Selective Biphasic Concentration System (SBCS) was applied. Based on liquid-liquid extraction, this method first extracts the target compounds from sample matrices into the acetonitrile phase, then selectively isolates siloxanes by adding a small amount of hexane. Synthetic musks remaining in the acetonitrile phase were reconstituted in hexane after nitrogen evaporation. This approach enabled efficient extraction and quantification of two compound groups with different solubility characteristics. The method was validated for accuracy and precision according to the CODEX guideline (CAC/GL 71-2009). The LODs were confirmed in the range of 0.21–7.45 ng/g, and the LOQs in the range of 0.55–19.18 ng/g. As all target compounds are listed as High Production Volume (HPV) chemicals, this method is expected to support regulatory monitoring in various foods and animal tissues, and may be applicable to environmental matrices through further studies. This research was supported by a grant (22194MFDS004) from the Ministry of Food and Drug Safety in 2025.​