2025년
한국질량분석학회 여름학술대회 및 총회
2025. 08.27 (수) ~ 2025. 08.29 (금)
부산항국제전시컨벤션센터(BPEX)
초록검색
| 제목 | Structural Characterization of Multiple GLP-1 Receptor Agonists using Electron Capture Dissociation |
|---|---|
| 작성자 | 김슬기 (한국애질런트테크놀로지스) |
| 발표구분 | 포스터발표 |
| 발표분야 | 4. Medical / Pharmaceutical Science |
| 발표자 |
Jinnyoung Choi (Agilent Technologies Korea) |
| 주저자 | Jinnyoung Choi (Agilent Technologies Korea) |
| 교신저자 |
Jinnyoung Choi (Agilent Technologies Korea) |
| 저자 |
Jinnyoung Choi (Agilent Technologies Korea) Rachel Franklin (Agilent Technologies, Inc., Corvallis, OR, United States) Julie Horner-Buxton (Agilent Technologies, Santa Clara, CA, United States) Joseph C. Meeuwsen (Agilent Technologies, Inc., Corvallis, OR, United States) Thomas E. Walker (Agilent Technologies, Lexington, MA, United States) Mike Hare (Agilent Technologies, Inc., Corvallis, OR, United States) |
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Over the past few years, the demand for GLP-1 receptor agonists for managing type 2 diabetes and obesity has surged. As new GLP-1 receptor agonists emerge, characterizing primary sequence and modification identities early in the development cycle is crucial. In this study we demonstrate in-depth LC-MS/MS sequence and modification characterization of multiple GLP-1 receptor agonists. Electron capture dissociation (ECD) facilitated the detailed characterization of GLP-1 receptor agonists by generating sequence-informative fragments while retaining modifications1 . ExDViewer was applied to analyze fragmentation patterns of GLP-1 receptor agonists with non-standard building blocks and modifications. |
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